Anti-tuberculosis treatment strategies and drug development: challenges and priorities
VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …
biological uncertainties remain and hamper progress. However, owing to collaborative …
Management of drug-resistant tuberculosis
Drug-resistant tuberculosis is a major public health concern in many countries. Over the past
decade, the number of patients infected with Mycobacterium tuberculosis resistant to the …
decade, the number of patients infected with Mycobacterium tuberculosis resistant to the …
[图书][B] Latent tuberculosis infection: updated and consolidated guidelines for programmatic management
World Health Organization - 2018 - apps.who.int
1.1 Background Latent tuberculosis infection (LTBI) is defined as a state of persistent
immune response to stimulation by Mycobacterium tuberculosis antigens with no evidence …
immune response to stimulation by Mycobacterium tuberculosis antigens with no evidence …
[图书][B] Guidelines for malaria vector control
World Health Organization - 2019 - apps.who.int
1.1 BACKGROUND Malaria remains an important cause of illness and death in children and
adults throughout the world, with 87 countries reporting one or more cases of malaria in …
adults throughout the world, with 87 countries reporting one or more cases of malaria in …
The global impact of household contact management for children on multidrug-resistant and rifampicin-resistant tuberculosis cases, deaths, and health-system costs in …
Background Estimates suggest that at least 30 000 children develop multidrug-resistant or
rifampicin-resistant tuberculosis each year. Despite household contact management (HCM) …
rifampicin-resistant tuberculosis each year. Despite household contact management (HCM) …
Barriers and facilitators of tuberculosis infection prevention and control in low-and middle-income countries from the perspective of healthcare workers: A systematic …
Tuberculosis remains a leading cause of death worldwide. Transmission is the dominant
mechanism sustaining the multidrug-resistant tuberculosis epidemic. Tuberculosis infection …
mechanism sustaining the multidrug-resistant tuberculosis epidemic. Tuberculosis infection …
Tuberculosis in children
PJ Holmberg, Z Temesgen, R Banerjee - Pediatrics in Review, 2019 - publications.aap.org
One of the most common infectious diseases worldwide, tuberculosis (TB) is estimated to
affect almost 1 in 3 individuals across the globe. Despite relatively cheap and accurate …
affect almost 1 in 3 individuals across the globe. Despite relatively cheap and accurate …
Prevalence of drug-resistant tuberculosis in Sudan: A systematic review and meta-analysis
Drug-resistant tuberculosis (DR-TB) is still one of the most critical issues impeding
worldwide TB control efforts. The aim of this systematic review and meta-analysis was to …
worldwide TB control efforts. The aim of this systematic review and meta-analysis was to …
Synergistic Effect of Q203 Combined with PBTZ169 against Mycobacterium tuberculosis
TQ Nguyen, BTB Hanh, S Jeon, BE Heo… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
ABSTRACT Q203 is a first-in-class drug candidate against Mycobacterium tuberculosis. In
its recently completed phase 2 clinical trial, Q203 reduced the number of live M. tuberculosis …
its recently completed phase 2 clinical trial, Q203 reduced the number of live M. tuberculosis …
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
Granulomas are complex lung lesions that are the hallmark of tuberculosis (TB).
Understanding antibiotic dynamics within lung granulomas will be vital to improving and …
Understanding antibiotic dynamics within lung granulomas will be vital to improving and …