The role and activity of SWI/SNF chromatin remodelers
T Bieluszewski, S Prakash, T Roulé… - Annual Review of Plant …, 2023 - annualreviews.org
SWITCH deficient SUCROSE NONFERMENTING (SWI/SNF) class chromatin remodeling
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …
transcription machinery. Classic models of transcription regulation focus on the recruitment …
Defining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
Determinants that enable disordered protein assembly into discrete condensed phases
Cells harbour numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …
Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates
Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas
Y Cheng, Z Shen, Y Gao, F Chen, H Xu, Q Mo… - Nature …, 2022 - nature.com
Oncoprotein SS18-SSX is a hallmark of synovial sarcomas. However, as a part of the SS18-
SSX fusion protein, SS18's function remains unclear. Here, we depict the structures of both …
SSX fusion protein, SS18's function remains unclear. Here, we depict the structures of both …
The role of phase-separated condensates in fusion oncoprotein–driven cancers
HK Shirnekhi, B Chandra… - Annual Review of Cancer …, 2023 - annualreviews.org
Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are
associated with many aggressive cancers with poor patient outcomes. Several FOs are now …
associated with many aggressive cancers with poor patient outcomes. Several FOs are now …
Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex
RB Davis, A Supakar, AK Ranganath… - Nature …, 2024 - nature.com
Prion-like domains (PLDs) are low-complexity protein sequences enriched within nucleic
acid-binding proteins including those involved in transcription and RNA processing. PLDs of …
acid-binding proteins including those involved in transcription and RNA processing. PLDs of …
Ectopic biomolecular phase transitions: fusion proteins in cancer pathologies
Biomolecular condensates are membraneless organelles (MLOs) that are enriched in
specific proteins and nucleic acids, compartmentalized to perform biochemical functions …
specific proteins and nucleic acids, compartmentalized to perform biochemical functions …
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer
Three-dimensional (3D) chromatin structure plays a critical role in development, gene
regulation, and cellular identity. Alterations to this structure can have profound effects on …
regulation, and cellular identity. Alterations to this structure can have profound effects on …