Mesenchymal stem cells as a source of dopaminergic neurons: a potential cell based therapy for Parkinson's disease

K Venkatesh, D Sen - Current Stem Cell Research & Therapy, 2017 - ingentaconnect.com
Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease
depend on well-characterized dopaminergic neuronal candidates that are healthy and show …

Stem cell therapy for neurodegenerative diseases: How do stem cells bypass the blood‐brain barrier and Home to the brain?

YC Chia, CE Anjum, HR Yee, Y Kenisi… - Stem Cells …, 2020 - Wiley Online Library
Blood‐brain barrier (BBB) is a term describing the highly selective barrier formed by the
endothelial cells (ECs) of the central nervous system (CNS) homeostasis by restricting …

Synergistic effect of BDNF and FGF2 in efficient generation of functional dopaminergic neurons from human mesenchymal stem cells

M Singh, A Kakkar, R Sharma, OP Kharbanda… - Scientific reports, 2017 - nature.com
To understand the process of neurogenesis, generation of functional dopaminergic
(DAergic) neurons from human mesenchymal stem cells (hMSCs) is important. BDNF has …

Conditioned Medium of Human Menstrual Blood-Derived Endometrial Stem Cells Protects Against MPP+-Induced Cytotoxicity in vitro

H Li, BH Yahaya, WH Ng, NM Yusoff… - Frontiers in molecular …, 2019 - frontiersin.org
Mesenchymal stem cells (MSCs) showed the potential to treat Parkinson's disease (PD).
However, it is unknown whether the conditioned medium of human menstrual blood-derived …

[HTML][HTML] Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome …

L Zhou, X Wang, X Wang, J An, X Zheng, D Han… - Biomedicine & …, 2022 - Elsevier
Mesenchymal stromal cells (MSCs) exhibit beneficial anti-inflammatory effects against
Parkinson's disease (PD) via immunomodulatory actions. However, the underlying …

Probiotic formulation VSL# 3 interacts with mesenchymal stromal cells to protect dopaminergic neurons via centrally and peripherally suppressing NOD-like receptor …

L Zhou, D Han, X Wang, Z Chen - Microbiology Spectrum, 2023 - Am Soc Microbiol
Systemic immunomodulation is increasingly recognized among the beneficial effects of
mesenchymal stromal cells (MSCs) in treatment of Parkinson's disease (PD), while the …

Harnessing stem cells and neurotrophic factors with novel technologies in the treatment of Parkinson's disease

M Conese, R Cassano, E Gavini… - Current Stem Cell …, 2019 - ingentaconnect.com
Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, oxidative stress
and neuroinflammation. The classical therapeutic approach with L-DOPA is not able to …

Unveiling the Neurodegenerative Alterations through Oral Stem Cells

M Tatullo, T Cocco, A Ferretta… - Journal of Dental …, 2024 - journals.sagepub.com
Parkinson's disease (PD) is a neurodegenerative condition characterized by the progressive
and selective loss of dopaminergic (DAergic) neurons in the midbrain. The replacement of …

22 (R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats

M Singh, M Jain, S Bose, A Halder, TC Nag… - Cell death …, 2021 - nature.com
Oxysterols play vital roles in the human body, ranging from cell cycle regulation and
progression to dopaminergic neurogenesis. While naïve human mesenchymal stem cells …

A Two‐Stage Process for Differentiation of Wharton's Jelly‐Derived Mesenchymal Stem Cells into Neuronal‐like Cells

Z Equbal, PN Baligar, M Srivastava… - Stem Cells …, 2021 - Wiley Online Library
With no permanent cure for neurodegenerative diseases, the symptoms reappear shortly
after the withdrawal of medicines. A better treatment outcome can be expected if the …