The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

Adolescent idiopathic scoliosis is a common disease with an overall prevalence of 0.47–
5.2% in the current literature. The female to male ratio ranges from 1.5: 1 to 3: 1 and …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …

Abstract Introduction Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate
targeting DLL3, an atypical Notch ligand expressed in SCLC tumors. We evaluated the …

Pluripotent stem cells are increasingly used to model different aspects of embryogenesis
and organ formation. Despite recent advances in in vitro induction of major mesodermal …

Background Congenital malformations can be manifested as combinations of phenotypes
that co-occur more often than expected by chance. In many such cases, it has proved difficult …