Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies
E Domingo, B Martínez-González… - Journal of …, 2023 - Am Soc Microbiol
Upon the emergence of SARS-CoV-2 in the human population, it was conjectured that for
this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned …
this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned …
Nanopore sequencing technology and its applications
P Zheng, C Zhou, Y Ding, B Liu, L Lu, F Zhu… - MedComm, 2023 - Wiley Online Library
Since the development of Sanger sequencing in 1977, sequencing technology has played a
pivotal role in molecular biology research by enabling the interpretation of biological genetic …
pivotal role in molecular biology research by enabling the interpretation of biological genetic …
Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals
Viral and host factors can shape SARS-CoV-2 evolution. However, little is known about
lineage-specific and vaccination-specific mutations that occur within individuals. Here, we …
lineage-specific and vaccination-specific mutations that occur within individuals. Here, we …
Impact of vaccination on SARS-CoV-2 evolution and immune escape variants
Vaccines and host genetic factors can influence the SARS-CoV-2 evolution and emergence
of new variants. Even vaccinated cases get affected as virus continues to evolve, raising …
of new variants. Even vaccinated cases get affected as virus continues to evolve, raising …
Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines
KA Kovalchik, DJ Hamelin, P Kubiniok… - Nature …, 2024 - nature.com
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …
Heterologous immunity induced by 1st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccine
RS Patel, B Agrawal - Frontiers in Immunology, 2022 - frontiersin.org
Severe acute respiratory syndrome virus-2 (SARS-CoV-2), the causative infectious agent of
the COVID-19 pandemic, has led to multiple (4-6) waves of infections worldwide during the …
the COVID-19 pandemic, has led to multiple (4-6) waves of infections worldwide during the …
SARS-CoV-2: an update on the biological interplay with the human host
Coronavirus Disease 2019 (COVID-19) is an infectious respiratory illness caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease, first identified in the …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease, first identified in the …
Rescuing low frequency variants within intra-host viral populations directly from Oxford Nanopore sequencing data
Infectious disease monitoring on Oxford Nanopore Technologies (ONT) platforms offers
rapid turnaround times and low cost. Tracking low frequency intra-host variants provides …
rapid turnaround times and low cost. Tracking low frequency intra-host variants provides …
SARS-CoV-2 within-host diversity of human hosts and its implications for viral immune evasion
B Xi, X Zeng, Z Chen, J Zeng, L Huang, H Du - MBio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously evolving,
bringing great challenges to the control of the virus. In the present study, we investigated the …
bringing great challenges to the control of the virus. In the present study, we investigated the …
Time-series sequences for evolutionary inferences
The application of genomics to evolutionary biology has provided unprecedented power and
resolution to in-vestigate processes like mutation ( Nachman and Crowell 2000; Rozhok and …
resolution to in-vestigate processes like mutation ( Nachman and Crowell 2000; Rozhok and …