“Reading” a new chapter in protozoan parasite transcriptional regulation
K Fleck, M Nitz, V Jeffers - PLoS Pathogens, 2021 - journals.plos.org
Protozoan parasites continue to cause a significant health and economic burden worldwide.
As infectious organisms, they pose unique and difficult challenges due to a level of …
As infectious organisms, they pose unique and difficult challenges due to a level of …
Identification of novel bromodomain inhibitors of Trypanosoma cruzi bromodomain factor 2 (TcBDF2) using a fluorescence polarization-based high-throughput assay
LE Tavernelli, VL Alonso, I Peña… - Antimicrobial Agents …, 2024 - journals.asm.org
Bromodomains are structural folds present in all eukaryotic cells that bind to other proteins
recognizing acetylated lysines. Most proteins with bromodomains are part of nuclear …
recognizing acetylated lysines. Most proteins with bromodomains are part of nuclear …
Essential Bromodomain TcBDF2 as a Drug Target against Chagas Disease
A Pezza, LE Tavernelli, VL Alonso… - ACS infectious …, 2022 - ACS Publications
Trypanosoma cruzi is a unicellular parasite that causes Chagas disease, which is endemic
in the American continent but also worldwide, distributed by migratory movements. A striking …
in the American continent but also worldwide, distributed by migratory movements. A striking …
Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci
Background Genomic organization and gene expression regulation in trypanosomes are
remarkable because protein-coding genes are organized into codirectional gene clusters …
remarkable because protein-coding genes are organized into codirectional gene clusters …
Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay
LE Tavernelli, VL Alonso, I Peña, E Rodríguez Araya… - bioRxiv, 2024 - biorxiv.org
Bromodomains are structural folds present in all eukaryotic cells that bind to other proteins
recognizing acetylated lysines. Most proteins with bromodomains are part of nuclear …
recognizing acetylated lysines. Most proteins with bromodomains are part of nuclear …
[HTML][HTML] Dynamics and Energetics of a Bromodomain in complex with bromosporine from Leishmania donovani
G Ropón-Palacios, M Chenet-Zuta… - Revista Colombiana …, 2023 - scielo.org.co
Leishmaniasis continues to be a neglected tropical disease, affecting people and animals
and causing significant economic losses. Therefore, there is interest in the study and …
and causing significant economic losses. Therefore, there is interest in the study and …