Surgery, neuroinflammation and cognitive impairment

A Alam, Z Hana, Z Jin, KC Suen, D Ma - EBioMedicine, 2018 - thelancet.com
Trauma experienced during surgery can contribute to the development of a systemic
inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical …

Perioperative neurocognitive disorder: state of the preclinical science

RG Eckenhoff, M Maze, Z Xie, DJ Culley… - …, 2020 - pmc.ncbi.nlm.nih.gov
The purpose of this white paper is to provide a succinct summary of the different
experimental approaches that have been used in preclinical post-operative cognitive …

Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction

X Tan, LL Qiu, J Sun - BioMed research international, 2021 - Wiley Online Library
Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …

Processed electroencephalogram monitoring and postoperative delirium: a systematic review and meta-analysis

KK MacKenzie, AM Britt-Spells, LP Sands… - …, 2018 - pmc.ncbi.nlm.nih.gov
Background Postoperative delirium complicates approximately 15%–20% of major
operations in patients≥ 65 years and is associated with adverse outcomes and increased …

Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders

C Cheng, H Wan, P Cong, X Huang, T Wu… - Journal of …, 2022 - Springer
Perioperative neurocognitive disorders (PND) is a common postoperative complication
associated with regional or general anesthesia and surgery. Growing evidence in both …

Postoperative delirium, neuroinflammation, and influencing factors of postoperative delirium: a review

MZ Xiao, CX Liu, LG Zhou, Y Yang, Y Wang - Medicine, 2023 - journals.lww.com
Postoperative delirium (POD) is an acute cognitive dysfunction that is mainly characterized
by memory impairment and disturbances in consciousness. POD can prolong the hospital …

Age-related perioperative neurocognitive disorders: experimental models and Druggable targets

OL Barreto Chang, KL Possin… - Annual Review of …, 2023 - annualreviews.org
With the worldwide increase in life span, surgical patients are becoming older and have a
greater propensity for postoperative cognitive impairment, either new onset or through …

Preventing postoperative cognitive dysfunction using anesthetic drugs in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis

K Zeng, J Long, Y Li, J Hu - International Journal of Surgery, 2023 - journals.lww.com
Postoperative cognitive dysfunction (POCD) is a common neurological system disorder in
surgical patients. The choice of anesthetic can potentially reduce POCD. The authors …

The effect of anesthetic depth on postoperative delirium in older adults: a systematic review and meta-analysis

Y Wang, H Zhu, F Xu, Y Ding, S Zhao, X Chen - BMC geriatrics, 2023 - Springer
Background Postoperative delirium (POD) is an important complication for older patients
and recent randomised controlled trials have showed a conflicting result of the effect of deep …

The correlation of the depth of anesthesia and postoperative cognitive impairment: a meta-analysis based on randomized controlled trials

X Lu, X Jin, S Yang, Y Xia - Journal of Clinical Anesthesia, 2018 - Elsevier
Study objective and background To comprehensively evaluate the associations between the
depth of anesthesia and postoperative delirium (POD) or postoperative cognitive dysfunction …