Post kala-azar dermal leishmaniasis in the Indian sub-continent: challenges and strategies for elimination
Visceral leishmaniasis (VL) is a severe and often fatal form of leishmaniasis caused by
Leishmania donovani in the Indian sub-continent. Post Kala-azar Dermal Leishmaniasis …
Leishmania donovani in the Indian sub-continent. Post Kala-azar Dermal Leishmaniasis …
Memory T cells: promising biomarkers for evaluating protection and vaccine efficacy against leishmaniasis
M Nateghi-Rostami, Y Sohrabi - Frontiers in Immunology, 2024 - frontiersin.org
Understanding the immune response to Leishmania infection and identifying biomarkers
that correlate with protection are crucial for developing effective vaccines. One intriguing …
that correlate with protection are crucial for developing effective vaccines. One intriguing …
Synthesis and physicochemical characterization of Zn–Al layered double hydroxides (LDHs) as a delivery system for amphotericin B: In vitro and in silico …
Leishmaniasis as a widespread neglected vector-borne protozoan disease is a major public
health concern in endemic areas due to 12 million people affected worldwide and 60,000 …
health concern in endemic areas due to 12 million people affected worldwide and 60,000 …
In vitro and in vivo therapeutic potentials of 6-gingerol in combination with amphotericin B for treatment of Leishmania major infection: Powerful synergistic and …
The ongoing conventional drugs for leishmaniasis treatment are insufficient. The present
study aimed to assess 6-gingerol alone and in combination with amphotericin B on …
study aimed to assess 6-gingerol alone and in combination with amphotericin B on …
CD4+ Th1 and Th17 responses and multifunctional CD8 T lymphocytes associated with cure or disease worsening in human visceral leishmaniasis
MNF de Franca, LS Rodrigues, AS Barreto… - Frontiers in …, 2024 - frontiersin.org
Introduction In VL, a proinflammatory phenotype is typically associated with enhanced
phagocytosis and a Th1 mediated immune response resulting in infection control. In …
phagocytosis and a Th1 mediated immune response resulting in infection control. In …
Immune dysregulation and inflammation causing hypopigmentation in post kala-azar dermal leishmaniasis: partners in crime?
R Sengupta, M Roy, NS Dey, PM Kaye… - Trends in …, 2023 - cell.com
Post kala-azar dermal leishmaniasis (PKDL), a heterogeneous dermal sequela of visceral
leishmaniasis (VL), is challenging in terms of its etiopathogenesis. Hypopigmentation is a …
leishmaniasis (VL), is challenging in terms of its etiopathogenesis. Hypopigmentation is a …
Leishmania donovani induces CD300a expression to dampen effector properties of CD11c+ dendritic and antigen activated CD8+ T cells
CD8+ T cells are an important regiment of adaptive immunity that play a decisive role in
elimination of many species of Leishmania parasite from the host. In visceral leishmaniasis …
elimination of many species of Leishmania parasite from the host. In visceral leishmaniasis …
Immunological role of keratinocytes in leishmaniasis
A Jafarzadeh, A Nair, S Jafarzadeh… - Parasite …, 2021 - Wiley Online Library
Following inoculation of Leishmania, a protozoan parasite, into the skin of a mammal, the
epidermal keratinocytes recognize the parasite and influence the local immune response …
epidermal keratinocytes recognize the parasite and influence the local immune response …
Differences in the Cellular Immune Response during and after Treatment of Sudanese Patients with Post-kala-azar Dermal Leishmaniasis, and Possible Implications …
Background The host cellular immune response associated with two treatments for post-kala-
azar dermal leishmaniasis (PKDL)-paromomycin plus miltefosine (Arm 1), and liposomal …
azar dermal leishmaniasis (PKDL)-paromomycin plus miltefosine (Arm 1), and liposomal …
Current and emerging therapies for the treatment of leishmaniasis
Introduction Leishmaniasis, a neglected protozoan illness caused by kinetoplastid
pathogens encompasses three major clinical subtypes: visceral, cutaneous and …
pathogens encompasses three major clinical subtypes: visceral, cutaneous and …