The health effects of vitamin D supplementation: evidence from human studies

R Bouillon, D Manousaki, C Rosen… - Nature Reviews …, 2022 - nature.com
Vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …

Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: a central and eastern European expert consensus statement

P Pludowski, I Takacs, M Boyanov, Z Belaya… - Nutrients, 2022 - mdpi.com
Vitamin D deficiency has a high worldwide prevalence, but actions to improve this public
health problem are challenged by the heterogeneity of nutritional and clinical vitamin D …

An update on the effects of vitamin D on the immune system and autoimmune diseases

C Sîrbe, S Rednic, A Grama, TL Pop - International journal of molecular …, 2022 - mdpi.com
Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis.
Experimental studies have shown that 1, 25-dihydroxyvitamin D (calcitriol) generates …

Critical appraisal of large vitamin D randomized controlled trials

S Pilz, C Trummer, V Theiler-Schwetz, MR Grübler… - Nutrients, 2022 - mdpi.com
As a consequence of epidemiological studies showing significant associations of vitamin D
deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular …

Vitamin D deficiency, osteoporosis and effect on autoimmune diseases and hematopoiesis: a review

M De Martinis, A Allegra, MM Sirufo, A Tonacci… - International journal of …, 2021 - mdpi.com
Vitamin D (VD) is essential for bone homeostasis, but it is also involved in pleiotropic effects
on various organs and tissues. In adults, VD deficiency can cause or exacerbate …

Vitamin D supplementation: upper limit for safety revisited?

R Rizzoli - Aging clinical and experimental research, 2021 - Springer
Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft
tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been …

Prevention and treatment of glucocorticoid-induced osteoporosis in adults: consensus recommendations from the Belgian bone club

MR Laurent, S Goemaere, C Verroken… - Frontiers in …, 2022 - frontiersin.org
Glucocorticoids are effective immunomodulatory drugs used for many inflammatory
disorders as well as in transplant recipients. However, both iatrogenic and endogenous …

Association of vitamin D levels, race/ethnicity, and clinical characteristics with COVID-19 test results

DO Meltzer, TJ Best, H Zhang, T Vokes… - JAMA network …, 2021 - jamanetwork.com
Importance Deficient (ie,< 20 ng/mL) or insufficient (ie, 20 to< 30 ng/mL) 25-hydroxyvitamin
D (also known ascalcifediol) levels are more common in Black individuals than White …

Vitamin D Supplementation: A Review of the Evidence Arguing for a Daily Dose of 2000 International Units (50 µg) of Vitamin D for Adults in the General Population

P Pludowski, WB Grant, SN Karras, A Zittermann, S Pilz - Nutrients, 2024 - mdpi.com
Vitamin D deficiency is considered a public health problem due to its worldwide high
prevalence and adverse clinical consequences regarding musculoskeletal health. In …

Vitamin D supplementation and clinical outcomes in severe COVID-19 patients—randomized controlled trial

J Domazet Bugarin, S Dosenovic, D Ilic, N Delic, I Saric… - Nutrients, 2023 - mdpi.com
COVID-19 symptoms vary from asymptomatic cases to moderate and severe illness with
patients needing hospitalization and intensive care treatment. Vitamin D is associated with …