Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Neutrophil recruitment is not only vital for host defense, but also relevant in pathological
inflammatory reactions, such as sepsis. Model systems have been established to examine …

Environmental pathogens move from ecological niches to mammalian hosts, requiring
adaptation to dramatically different environments. Microbes that disseminate farther …

The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the
passage of molecules and microorganisms. Despite this barrier, however, the fungal …

Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening
disease. These fungi commonly enter their host via inhalation into the lungs where they …

Intravital microscopy (IVM) study approach offers several advantages over in vitro, ex vivo,
and 3D models. IVM provides real-time imaging of cellular events, which provides us a …

Aspergillus fumigatus is an opportunistic fungal pathogen that can cause life-threatening
invasive lung infections in immunodeficient patients. The cellular and molecular processes …

In this review, we discuss intravital microscopy of immune cells, starting from its historic
origins to current applications in diverse organs. It is clear from a quantitative review of the …

Acute lung injury (ALI) is the leading cause of morbidity and mortality in critically ill patients.
Neutrophil extracellular traps (NETs) have been well documented in the ALI model of …

Cryptococcal meningoencephalitis is a fungal infection that predominantly affects
immunocompromised patients and is uniformly fatal if left untreated. Timely diagnosis is …