Therapeutic potential of targeting the ghrelin pathway

G Colldén, MH Tschöp, TD Müller - International Journal of Molecular …, 2017 - mdpi.com
Ghrelin was discovered in 1999 as the endogenous ligand of the growth-hormone
secretagogue receptor 1a (GHSR1a). Since then, ghrelin has been found to exert a plethora …

[HTML][HTML] New aspects of corpus luteum regulation in physiological and pathological conditions: involvement of adipokines and neuropeptides

E Mlyczyńska, M Kieżun, P Kurowska, M Dawid, K Pich… - Cells, 2022 - mdpi.com
The corpus luteum is a small gland of great importance because its proper functioning
determines not only the appropriate course of the estrous/menstrual cycle and embryo …

The role of the gastric hormones ghrelin and nesfatin-1 in reproduction

MA Schalla, A Stengel - International Journal of Molecular Sciences, 2021 - mdpi.com
Ghrelin and nesfatin-1 are enteroendocrine peptide hormones expressed in rat X/A-like and
human P/D1cells of the gastric mucosa. Besides their effect on food intake, both peptides …

Expression of apelin and apelin receptor (APJ) in porcine ovarian follicles and in vitro effect of apelin on steroidogenesis and proliferation through APJ activation and …

A Rak, E Drwal, C Rame, K Knapczyk-Stwora… - Theriogenology, 2017 - Elsevier
Apelin was thought to be an adipocyte-specific hormone, but recent studies indicate a link
between apelin and female reproductive function. Using real-time PCR, immunoblotting …

SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions

Y Han, H Luo, H Wang, J Cai, Y Zhang - Apoptosis, 2017 - Springer
SIRT1, a member of the sirtuin family, has recently emerged as a vital molecule in controlling
ovarian function. The aims of the present study were to investigate SIRT1 expression and …

The ghrelin axis—does it have an appetite for cancer progression?

LK Chopin, I Seim, CM Walpole… - Endocrine …, 2012 - academic.oup.com
Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHSR), is a peptide
hormone with diverse physiological roles. Ghrelin regulates GH release, appetite and …

Paracrine interactions between mesenchymal stem cells affect substrate driven differentiation toward tendon and bone phenotypes

RI Sharma, JG Snedeker - PloS one, 2012 - journals.plos.org
We investigated substrate dependent paracrine signaling between subpopulations of bone
marrow stromal cells (BMSCs) that may affect the formation, or perhaps malformation, of the …

Ghrelin inhibits cisplatin‑induced MDA‑MB‑231 breast cancer cell apoptosis via PI3K/Akt/mTOR signaling

J Zhang, T Xie - Experimental and Therapeutic …, 2020 - spandidos-publications.com
Ghrelin is a multi‑functional peptide, its role on cancer cell apoptosis remains controversial.
The present study examined the effects and mechanisms of ghrelin on cisplatin‑induced …

Beyond the metabolic role of ghrelin: a new player in the regulation of reproductive function

G Muccioli, T Lorenzi, M Lorenzi, C Ghè, E Arnoletti… - Peptides, 2011 - Elsevier
Ghrelin is a gastric peptide, discovered by Kojima et al.(1999)[55] as a result of the search
for an endogenous ligand interacting with the “orphan receptor” GHS-R1a (growth hormone …

Vaspin in the pig ovarian follicles: Expression and regulation by different hormones

P Kurowska, E Mlyczyńska, A Barbe, C Staub… - …, 2019 - rep.bioscientifica.com
Vaspin, also known as visceral adipose tissue-derived serine protease inhibitor, is a
member of the serine protease inhibitor family. Its expression is associated with obesity …