The activity-dependent trafficking of AMPA receptors (AMPAR) mediates synaptic strength
and plasticity, while the perturbed trafficking of the receptors of different subunit …

Synaptic plasticity enhances or reduces connections between neurons, affecting learning
and memory. Postsynaptic AMPARs mediate greater than 90% of the rapid excitatory …

Physiological pain serves as a warning of exposure to danger and prompts us to withdraw
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …

The pathogenic mechanisms underlying neuropathic pain still remain largely unknown. In
this study, we investigated whether spinal BDNF contributes to dorsal horn LTP induction …

Background Cancer pain is a pervasive clinical symptom impairing life quality. Vascular
endothelial growth factor A has been well studied in tumor angiogenesis and is recognized …

Abstract The α-amino-3-hydroxy-5-methylisoxazole-4-isoxazolepropionic acid receptor
(AMPAR) has been recognized to play a vital role in the development of neuropathic pain …

The dorsal horn (DH) neurons of the spinal cord play a critical role in nociceptive input
integration and processing in the central nervous system. Engaged neuronal classes and …

Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both
spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca 2+ permeable …

OBJECTIVE Rapid-stretch nerve injuries are among the most devastating lesions to
peripheral nerves, yielding unsatisfactory functional outcomes. No animal model has yet …

Acute physiological pain, the unpleasant sensory response to a noxious stimulus, is
essential for animals and humans to avoid potential injury. Pathological pain that persists …