Vanadium and insulin: Partners in metabolic regulation

S Treviño, A Diaz - Journal of Inorganic Biochemistry, 2020 - Elsevier
Since the 1970s, the biological role of vanadium compounds has been discussed as insulin-
mimetic or insulin-enhancer agents. The action of vanadium compounds has been …

Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease

M Zheng, P Wang - 3 Biotech, 2021 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease, also regarded as
“type 3 diabetes” for the last few years because of the brain insulin resistance (IR) and …

Integrated analysis of mRNA-seq and miRNA-seq in the liver of Pelteobagrus vachelli in response to hypoxia

G Zhang, S Yin, J Mao, F Liang, C Zhao, P Li, G Zhou… - Scientific reports, 2016 - nature.com
Pelteobagrus vachelli is a well-known commercial species in Asia. However, a sudden lack
of oxygen will result in mortality and eventually to pond turnover. Studying the molecular …

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

Y Yoneyama, P Lanzerstorfer, H Niwa, T Umehara… - Elife, 2018 - elifesciences.org
Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF
activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis …

[HTML][HTML] Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

R Wagner, G Stübiger, D Veigel, M Wuczkowski… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Receptor-PI3K-mTORC1 signaling and fatty acid synthase (FASN)-regulated lipid
biosynthesis harbor numerous drug targets and are molecularly connected. We hypothesize …

Subcellular dynamic immunopatterning of cytosolic protein complexes on microstructured polymer substrates

R Hager, U Müller, N Ollinger, J Weghuber… - ACS …, 2021 - ACS Publications
Analysis of protein–protein interactions in living cells by protein micropatterning is currently
limited to the spatial arrangement of transmembrane proteins and their corresponding …

Insulin Mimetic Properties of Extracts Prepared from Bellis perennis

R Haselgrübler, V Stadlbauer, F Stübl, B Schwarzinger… - Molecules, 2018 - mdpi.com
Diabetes mellitus (DM) and consequential cardiovascular diseases lead to millions of
deaths worldwide each year; 90% of all people suffering from DM are classified as Type 2 …

Highly modular protein micropatterning sheds light on the role of clathrin-mediated endocytosis for the quantitative analysis of protein-protein interactions in live cells

P Lanzerstorfer, U Müller, K Gordiyenko, J Weghuber… - Biomolecules, 2020 - mdpi.com
Protein micropatterning is a powerful tool for spatial arrangement of transmembrane and
intracellular proteins in living cells. The restriction of one interaction partner (the bait, eg, the …

A simplified and robust activation procedure of glass surfaces for printing proteins and subcellular micropatterning experiments

T Karimian, R Hager, A Karner, J Weghuber… - Biosensors, 2022 - mdpi.com
Depositing biomolecule micropatterns on solid substrates via microcontact printing (µCP)
usually requires complex chemical substrate modifications to initially create reactive surface …

PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin

R Datta, D Mukherjee, MJ Podolsky, CD Yang… - Journal of Biological …, 2024 - ASBMB
Integrins are cell adhesion receptors that dimerize to mediate cell–cell interactions and
regulate processes, including proliferation, inflammation, and tissue repair. The role of …