This review summarizes the changes in the 5th edition of the WHO Classification of
Endocrine and Neuroendocrine Tumors that relate to the thyroid gland. The new …

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid
cancer. Since the guidelines for the management of ATC by the American Thyroid …

The incidence of thyroid cancer (TC) has increased worldwide over the past four decades.
TC is divided into three main histological types: differentiated (papillary and follicular TC) …

Purpose We report the efficacy and safety of dabrafenib (BRAF inhibitor) and trametinib
(MEK inhibitor) combination therapy in BRAF V600E–mutated anaplastic thyroid cancer, a …

Genomic profiling shows that many solid tumors are characterized by specific driver
aberrations, and this has expanded the therapeutic options for many patients. The mitogen …

Purpose: To define the genetic landscape of advanced differentiated and anaplastic thyroid
cancer (ATC) and identify genetic alterations of potential diagnostic, prognostic, and …

PURPOSE Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always
fatal and lacks effective systemic treatment options for patients with BRAF-wild type disease …

BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …

Background: Anaplastic thyroid carcinoma (ATC) and metastatic poorly differentiated thyroid
carcinomas (PDTCs) are rare aggressive malignancies with poor overall survival (OS) …