Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene
therapy owing to its minimal pathogenicity and ability to establish long-term gene expression …

Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic
diseases. Nonsense mutations convert a sense codon that is decoded by tRNA into a …

RNA engineering has immense potential to drive innovation in biotechnology and medicine.
Despite its importance, a versatile platform for the automated design of functional RNA is still …

Translation is pervasive outside of canonical coding regions, occurring in long noncoding
RNAs, canonical untranslated regions and introns,,–, especially in ageing …

Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …

Cognate tRNAs deliver specific amino acids to translating ribosomes according to the
standard genetic code, and three codons with no cognate tRNAs serve as stop codons …

Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

Programmable RNA pseudouridylation has emerged as a new type of RNA base editor to
suppress premature termination codons (PTCs) that can lead to truncated and nonfunctional …

Missense mutations account for approximately 50% of pathogenic mutations in human
genetic diseases, and most lack effective treatments. Gene therapies, gene editing, and …