This review provides comprehensive information about the advances in gene therapy in the
anterior segment of the eye, including cornea, conjunctiva, lacrimal gland, and trabecular …

Proteostasis refers to all the processes that maintain the correct expression level, location,
folding and turnover of proteins, essential to organismal survival. Both inside cells and in …

Human periostin is a 78–91 kDa matricellular protein implicated in extracellular matrix
remodeling, tumor development, metastasis, and inflammatory diseases like atopic …

Corneal diseases affect 4.2 million people worldwide and are a leading cause of vision
impairment and blindness. Current treatments for corneal diseases, such as antibiotics …

Diabetic nephropathy (DN) is a microvascular disease caused by diabetes. Tanshinone IIA
has been indicated to ameliorate streptozotocin-induced DN. This study explores the effect …

Conjunctival defects severely impair ocular surface homeostasis and vision. However, the
existing conjunctival reconstruction methods are still unable to achieve satisfactory …

Dickkopf‐related protein (DKK) 3, a member of the DKK family, is a secreted glycoprotein
that acts as a modulator of Wnt signaling in organogenesis and carcinogenesis. Recent …

Purpose To provide a brief summary and comparison of the most recent literature on
available and theorized treatment modalities for classic lattice corneal dystrophy (LCD). This …

One major purpose of the IC3D Corneal Dystrophy Nomenclature Revision was to include
genetic information with a goal of facilitating investigation into the pathogenesis, treatment …

Protein aggregation has been one of the leading triggers of various disease conditions, such
as Alzheimer's, Parkinson's and other amyloidosis. TGFBI-associated corneal dystrophies …