Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

Abstract G-quadruplexes (G4s), higher-order DNA and RNA secondary structures featuring
guanine-rich nucleic acid sequences with various conformations, are widely distributed in …

Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

Genome-wide studies of DNA replication origins revealed that origins preferentially
associate with an Origin G-rich Repeated Element (OGRE), potentially forming G …

Abstract G-quadruplex (G4) structures have been predicted in the genomes of many
organisms and proven to play regulatory roles in diverse cellular activities. However, there is …

Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …

G-quadruplexes are four-stranded helical nucleic acid structures formed by guanine-rich
sequences. A considerable number of studies have revealed that these noncanonical …

It is well known that certain non B-DNA structures, including G-quadruplexes, are key
elements that can regulate gene expression. Here, we explore the theory that DNA …

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated cytosine–phosphate–
guanine (CpG) motifs trigger the immune response by stimulating endosomal Toll-like …

Glaucoma is a heterogenous, chronic, progressive group of eye diseases, which results in
irreversible loss of vision. There are several types of glaucoma, whereas the primary open …