Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
[HTML][HTML] The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis
J Muñoz-Garcia, D Cochonneau, S Télétchéa… - Theranostics, 2021 - ncbi.nlm.nih.gov
Macrophages are specialized cells that control tissue homeostasis. They include non-
resident and tissue-resident macrophage populations which are characterized by the …
resident and tissue-resident macrophage populations which are characterized by the …
Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: A too simplistic explanation that does not take into account the …
V Forest, J Pourchez - Materials Science and Engineering: C, 2017 - Elsevier
The internalization of nanoparticles by cells (and more broadly the nanoparticle/cell
interaction) is a crucial issue both for biomedical applications (for the design of nanocarriers …
interaction) is a crucial issue both for biomedical applications (for the design of nanocarriers …
Macrophages associated with tumors as potential targets and therapeutic intermediates
S Vinogradov, G Warren, X Wei - Nanomedicine, 2014 - Taylor & Francis
Tumor-associated macrophages (TAMs) form approximately 50% of tumor mass. TAMs were
shown to promote tumor growth by suppressing immunocompetent cells, inducing …
shown to promote tumor growth by suppressing immunocompetent cells, inducing …
Impact of silica nanoparticle surface chemistry on protein corona formation and consequential interactions with biological cells
A Kurtz-Chalot, C Villiers, J Pourchez… - Materials Science and …, 2017 - Elsevier
Nanoparticles (NP) physico-chemical features greatly influence NP/cell interactions. NP
surface functionalization is often used to improve NP biocompatibility or to enhance cellular …
surface functionalization is often used to improve NP biocompatibility or to enhance cellular …
[HTML][HTML] In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?
The interfacing of colloidal nanoparticles with mammalian cells is now well into its second
decade. In this review our goal is to highlight the more generally accepted concepts that we …
decade. In this review our goal is to highlight the more generally accepted concepts that we …
The coating makes the difference: Acute effects of iron oxide nanoparticles on Daphnia magna
J Baumann, J Köser, D Arndt, J Filser - Science of the Total Environment, 2014 - Elsevier
The surface of nanoparticles (NP) is often functionalized with a capping agent to increase
their colloidal stability. Having a strong effect on the characteristics of NP, the coating might …
their colloidal stability. Having a strong effect on the characteristics of NP, the coating might …
Electrostatic interactions favor the binding of positive nanoparticles on cells: A reductive theory
V Forest, M Cottier, J Pourchez - Nano Today, 2015 - Elsevier
It is acknowledged that physico-chemical features of nanoparticles have a major impact on
their uptake, and especially their surface charge. A widespread observation is that positively …
their uptake, and especially their surface charge. A widespread observation is that positively …
Synthesis of nanoparticles, their biocompatibility, and toxicity behavior for biomedical applications
A Gautam, FCJM van Veggel - Journal of Materials Chemistry B, 2013 - pubs.rsc.org
Nanomaterials research has in part been focused on their use in biomedical applications for
more than several decades. However, in recent years this field has been developing to a …
more than several decades. However, in recent years this field has been developing to a …
Effects of surface charge of hyperbranched polymers on cytotoxicity, dynamic cellular uptake and localization, hemotoxicity, and pharmacokinetics in mice
L Chen, JD Simpson, AV Fuchs, BE Rolfe… - Molecular …, 2017 - ACS Publications
Nanoscaled polymeric materials are increasingly being investigated as pharmaceutical
products, drug/gene delivery vectors, or health-monitoring devices. Surface charge is one of …
products, drug/gene delivery vectors, or health-monitoring devices. Surface charge is one of …