The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …

The renin-angiotensin system (RAS) plays a crucial role in cardiovascular regulations and
its modulation is a challenging target for the vast majority of cardioprotective strategies …

Angiotensin II (Ang II) is well-considered to be the principal effector of the renin–angiotensin
system (RAS), which binds with strong affinity to the angiotensin II type 1 (AT1R) and type 2 …

Introduction: The aim of this study was to investigate the potential role of melatonin in the
prevention of chemotherapy-induced nephrotoxicity at the preclinical level. Areas covered …

Human life expectancy has increased over the past 50 years due to scientific and medical
advances and higher food availability. However, overweight and obesity affect more than …

The purpose of this study is to evaluate the likely defensive impact of Ajwa date aqueous
extract (AJDAE) in alleviating the nephrotoxicity generated by doxorubicin (DOX) injection in …

There are a number of therapeutic targets to treat organ fibrosis that are under investigation
in preclinical models. There is increasing evidence that stimulation of the angiotensin II type …

The angiotensin AT2‐receptor is a main receptor of the protective arm of the renin‐
angiotensin system. Understanding of this unconventional G‐protein coupled receptor has …

This study was performed to examine whether clindamycin could protect against doxorubicin
(DOX)-induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for …