Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Lung cancer is the leading cause of cancer-related mortality worldwide. Although the
PI3K/Akt/mTOR signaling pathway has recently been considered as one of the most altered …

Cancer cells have a characteristic metabolism, mostly caused by alterations in signal
transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to …

Lung cancer is the most frequent cancer with an aggressive clinical course and high
mortality rates. Most cases are diagnosed at advanced stages when treatment options are …

In non-small cell lung cancer (NSCLC), the most frequent oncogenic mutation in western
countries is KRAS, for which, however, there remains no clinically approved targeted …

Palmitoylation is essential for the classic hallmarks of cancers through regulating protein
stability and protein-protein interactions. ZDHHC22, as a well-known member of …

Mutant p53 proteins result from missense mutations in the TP53 gene, the most mutated in
human cancer, and have been described to contribute to cancer initiation and progression …

Drug resistance and tumor heterogeneity are formidable challenges in cancer medicine,
which is particularly relevant for KRAS-mutant cancers, the epitome of malignant tumors …

Deregulation of chromatin modifiers plays an essential role in the pathogenesis of
medulloblastoma, the most common paediatric malignant brain tumour. Here, we identify a …

The recently approved KRASG12C mutation-specific inhibitors sotorasib and adagrasib
(KRASG12C-I) represent a promising therapy for KRASG12C-driven non-small cell lung …