One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …

Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …

Phagocytosis is a specialized process that enables cellular ingestion and clearance of
microbes, dead cells and tissue debris that are too large for other endocytic routes. As such …

The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated
in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to …

Antigen receptor signalling activates the canonical NF-κB pathway via the CARD11/BCL10/
MALT1 (CBM) signalosome involving key, yet ill-defined roles for linear ubiquitination. The …

Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This
may be of particular importance in the context of immune receptors, such as the B cell …

Abstract Transmembrane protein 30A (TMEM30A) maintains the asymmetric distribution of
phosphatidylserine, an integral component of the cell membrane and 'eat-me'signal …

Toll-like receptors (TLRs) play an important role in immune responses to pathogens by
transducing signals in innate immune cells in response to microbial products. TLRs are also …