Simple Summary Drug repurposing is emerging as a promising avenue for addressing
clinical challenges in treating drug-resistant and metastatic cancers. As a case study, some …

Dysregulated pH is now recognised as a hallmark of cancer. Recent evidence has revealed
that the endosomal pH regulator Na+/H+ exchanger NHE9 is upregulated in colorectal …

Although suppressed cAMP levels have been linked to cancer for nearly five decades, the
molecular basis remains uncertain. Here, we identify endosomal pH as a novel regulator of …

Glioblastoma (GBM) is the most common and aggressive brain cancer in adults. The
standard treatment is brutal and has changed little in 20 years, and more than 85% of …

Objective: Trafficking of GLUcose Transporter isoform 4 (GLUT4) from the adipocyte
vesicular pool to the cell surface is tightly regulated by insulin to maintain glucose …

High-grade glioma (HGG) is an aggressive brain cancer with an overall 5-year survival rate
of less than 10% in adults and less than 2% in children. Despite significant research efforts …

High-grade glioma (HGG) is an aggressive brain cancer with an overall 5-year survival rate
of less than 10% in adults and less than 2% in children. Despite significant research efforts …

The sodium/hydrogen exchangers NHE6 and NHE9 have overlapping distribution in
endosomes where they regulate luminal pH to affect important cellular processes such as …