Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
The human cortex comprises diverse cell types that emerge from an initially uniform
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
Mouse retinal cell atlas: molecular identification of over sixty amacrine cell types
Amacrine cells (ACs) are a diverse class of interneurons that modulate input from
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …
Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain
Thalamocortical axons must cross a complex cellular terrain through the developing
forebrain, and this terrain has to be understood for us to learn how thalamocortical axons …
forebrain, and this terrain has to be understood for us to learn how thalamocortical axons …
In and out from the cortex: development of major forebrain connections
E Leyva-Díaz, G López-Bendito - Neuroscience, 2013 - Elsevier
In this review we discuss recent advances in the understanding of the development of
forebrain projections attending to their origin, fate determination, and axon guidance. Major …
forebrain projections attending to their origin, fate determination, and axon guidance. Major …
Spatiotemporal molecular dynamics of the developing human thalamus
The thalamus plays a central coordinating role in the brain. Thalamic neurons are organized
into spatially distinct nuclei, but the molecular architecture of thalamic development is poorly …
into spatially distinct nuclei, but the molecular architecture of thalamic development is poorly …
Prenatal thalamic waves regulate cortical area size prior to sensory processing
V Moreno-Juan, A Filipchuk, N Antón-Bolanos… - Nature …, 2017 - nature.com
The cerebral cortex is organized into specialized sensory areas, whose initial territory is
determined by intracortical molecular determinants. Yet, sensory cortical area size appears …
determined by intracortical molecular determinants. Yet, sensory cortical area size appears …
Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming
Neural cell diversity is essential to endow distinct brain regions with specific functions.
During development, progenitors within these regions are characterized by specific gene …
During development, progenitors within these regions are characterized by specific gene …
Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice
N Antón-Bolaños, A Sempere-Ferràndez… - Science, 2019 - science.org
The mammalian brain's somatosensory cortex is a topographic map of the body's sensory
experience. In mice, cortical barrels reflect whisker input. We asked whether these cortical …
experience. In mice, cortical barrels reflect whisker input. We asked whether these cortical …
Specification of diverse cell types during early neurogenesis of the mouse cerebellum
JW Wizeman, Q Guo, EM Wilion, JYH Li - Elife, 2019 - elifesciences.org
We applied single-cell RNA sequencing to profile genome-wide gene expression in about
9400 individual cerebellar cells from the mouse embryo at embryonic day 13.5. Reiterative …
9400 individual cerebellar cells from the mouse embryo at embryonic day 13.5. Reiterative …
Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling
D Peukert, S Weber, A Lumsden, S Scholpp - PLoS biology, 2011 - journals.plos.org
Initial axial patterning of the neural tube into forebrain, midbrain, and hindbrain primordia
occurs during gastrulation. After this patterning phase, further diversification within the brain …
occurs during gastrulation. After this patterning phase, further diversification within the brain …