The common variable immunodeficiency disorders are a mixed group of heterogeneous
conditions linked by lack of immunoglobulin production and primary antibody failure. This …

Sophisticated genetic tools have made possible the identification of the genes responsible
for most well-described immunodeficiencies in the past 15 years. Mutations in Btk …

Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently
not well understood. Most affected individuals are simplex cases, but both autosomal …

Abstract The European Common Variable Immunodeficiency Disorders registry was started
in 1996 to define distinct clinical phenotypes and determine overlap within individual …

Antibody deficiencies constitute the largest group of symptomatic primary immunodeficiency
diseases. In several patients, mutations in CD19 have been found to underlie disease …

Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …

Common variable immune deficiency (CVID) is the most frequent symptomatic primary
immune deficiency in adults. The standard of care is intravenous immunoglobulin (IVIG) or …

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary
immunodeficiency characterized by recurrent infections, hypogammaglobulinemia and poor …

Corals rely on photosynthesis by their endosymbiotic dinoflagellates (Symbiodinium spp.) to
form the basis of tropical coral reefs. High sea surface temperatures driven by climate …

Common variable immunodeficiency disorders (CVIDs) are the most frequent symptomatic
primary immune deficiency condition in adults. The genetic basis for the condition is not …