Tuberculosis treatment monitoring and outcome measures: new interest and new strategies
J Heyckendorf, SB Georghiou, N Frahm… - Clinical microbiology …, 2022 - Am Soc Microbiol
Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …
global public health threat. A significant challenge for TB control efforts has been the …
Defining dormancy in mycobacterial disease
Tuberculosis remains a threat to global health and recent attempts to shorten therapy have
not succeeded mainly due to cases of clinical relapse. This has focussed attention on the …
not succeeded mainly due to cases of clinical relapse. This has focussed attention on the …
Extreme drug tolerance of Mycobacterium tuberculosis in caseum
Tuberculosis (TB) recently became the leading infectious cause of death in adults, while
attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance …
attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance …
Triacylglycerols: Fuelling the Hibernating Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) has the remarkable ability to persist with a modified
metabolic status and phenotypic drug tolerance for long periods in the host without …
metabolic status and phenotypic drug tolerance for long periods in the host without …
[HTML][HTML] Localization and phenotyping of tuberculosis bacteria using a combination of deep learning and SVMs
M Zachariou, O Arandjelović, E Dombay… - Computers in Biology …, 2023 - Elsevier
Successful treatment of pulmonary tuberculosis (TB) depends on early diagnosis and careful
monitoring of treatment response. Identification of acid-fast bacilli by fluorescence …
monitoring of treatment response. Identification of acid-fast bacilli by fluorescence …
Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials
PPJ Phillips, CM Mendel, DA Burger, AM Crook… - BMC medicine, 2016 - Springer
Background Despite recent increased clinical trials activity, no regimen has proved able to
replace the standard 6-month regimen for drug-sensitive tuberculosis. Understanding the …
replace the standard 6-month regimen for drug-sensitive tuberculosis. Understanding the …
Breaking fat! How mycobacteria and other intracellular pathogens manipulate host lipid droplets
C Barisch, T Soldati - Biochimie, 2017 - Elsevier
Tuberculosis (Tb) is a lung infection caused by Mycobacterium tuberculosis (Mtb). With one
third of the world population latently infected, it represents the most prevalent bacterial …
third of the world population latently infected, it represents the most prevalent bacterial …
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria
Mycobacteria share with other actinomycetes the ability to produce large quantities of
triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known …
triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known …
The role of moxifloxacin in tuberculosis therapy
SH Gillespie - European Respiratory Review, 2016 - Eur Respiratory Soc
Tuberculosis (TB) remains a global threat with more than 9 million new infections. Treatment
remains difficult and there has been no change in the duration of the standard regimen since …
remains difficult and there has been no change in the duration of the standard regimen since …
Real-time monitoring of live mycobacteria with a microfluidic acoustic-Raman platform
Tuberculosis (TB) remains a leading cause of death worldwide. Lipid rich, phenotypically
antibiotic tolerant, bacteria are more resistant to antibiotics and may be responsible for …
antibiotic tolerant, bacteria are more resistant to antibiotics and may be responsible for …