Multiple neurodegenerative diseases are characterized by single-protein dysfunction and
aggregation. Treatment strategies for these diseases have often targeted downstream …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …

Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in
cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …

Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of
biological functions that transcend lipid metabolism. Lipoprotein receptors have broad …

The apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for late-onset,
sporadic Alzheimer's disease, likely increasing risk by altering amyloid-β (Aβ) accumulation …

Over half a century ago, DS Falconer first reported a mouse with a reeling gate. Four
decades later, the Reln gene was isolated and identified as the cause of the reeler …

Accumulation of extracellular amyloid β peptide (Aβ), generated from amyloid precursor
protein (APP) processing by β-and γ-secretases, is toxic to neurons and is central to the …

The amyloid precursor protein (APP) is subject to alternative pathways of proteolytic
processing, leading either to production of the amyloid-β (Aβ) peptides or to non …