Changes of intracellular Ca2+ concentration regulate many aspects of cardiac myocyte
function. About 99% of the cytoplasmic calcium in cardiac myocytes is bound to buffers, and …

Throughout history, muscle research has led to numerous scientific breakthroughs that have
brought insight to a more general understanding of all biological processes. Potentially one …

Members of the parvalbumin (PV) family of calcium (Ca2+) binding proteins (CBPs) share a
relatively high level of sequence similarity. However, their Ca2+ affinities and selectivities …

Aberrant myofilament Ca 2+ sensitivity is commonly observed with multiple cardiac
diseases, especially familial cardiomyopathies. Although the etiology of the …

Parvalbumin (PA) is a classical EF-hand calcium-binding protein of muscle, neuronal, and
other tissues, and a major fish allergen. Although certain apo-PAs lack tertiary structure …

Ryanodine receptor channels at calcium release sites of cardiac myocytes operate on the
principle of calcium-induced calcium release. In vitro experiments revealed competition of …

Parvalbumin (PV) is a globular calcium (Ca2+)-selective protein expressed in a variety of
biological tissues. Our computational studies of the rat β-parvalbumin (β-PV) isoform seek to …

Cardiac gene delivery of parvalbumin (Parv), an EF-hand Ca 2+ buffer, has been studied as
a therapeutic strategy for diastolic heart failure, in which slow Ca 2+ reuptake is an important …

Plants commonly respond to stressors by modulating the expression of a large family of
calcium binding proteins including isoforms of the ubiquitous signaling protein calmodulin …

Recently we found two highly conserved structural motifs in the proteins of the EF-hand
calcium binding protein family. These motifs provide a supporting scaffold for the Ca 2+ …