Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4
MPa and 31.1° C. Given the request for consumption of a green solvent for the environment …

The poor solubility of significant number of Active Pharmaceutical Ingredients (APIs) has
become a major challenge in the drug development process. Drugs with poor solubility are …

During the last few decades the nanomedicine sector has emerged as a feasible and
effective solution to the problems faced by the high percentage of poorly water-soluble …

A method of rapid expansion of supercritical solutions with solid cosolvent (RESS-SC) was
applied, for the first time, to precipitate nanoparticles of Letrozole (LTZ). Solubility of LTZ, as …

The interest of the use of supercritical fluids, especially supercritical CO2, for particle
engineering over the last years has received attention from the pharmaceutical industry …

Nanosizing of pharmaceutical drug particles is one of the most important drug delivery
platforms approaches for the commercial development of poorly water-soluble drug …

Nanoagrochemicals, such as nanopesticides, nanofertilizers or plant growth stimulating
nanosystems, were primarily designed to increase solubility, enhance bioavailability …

The present study practiced ultrasonic-assisted rapid expansion of a supercritical CO 2
solution into a liquid solvent (US-RESOLV) process for the synthesis of nanoparticles (NPs) …