Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to mapping senescent cells in tissues such as the absence of specific …

Modern drug discovery approaches often use high-content imaging to systematically study
the effect on cells of large libraries of chemical compounds. By automatically screening …

Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Cellular senescence is a stress response involved in ageing and diverse disease processes
including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest …

Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer
biology and develop novel precision medicine therapeutics. However, utilizing TOs for …

Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect
associated with a range of chronic and age‐related diseases. Since the discovery of the first …

Cellular senescence is a stress response with broad pathophysiological implications.
Senotherapies can induce senescence to treat cancer or eliminate senescent cells to …

An increased life span and accompanying nutritional affluency have led to a rapid increase
in diseases associated with aging, such as obesity and type 2 diabetes, imposing a …