Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

A wide range of cognitive deficits, including memory loss associated with hippocampal
dysfunction, have been widely reported in cancer survivors who received chemotherapy …

Melatonin is registered to treat circadian rhythm sleep–wake disorders and insomnia in
patients aged 55 years and over. The essential role of the circadian sleep rhythm in the …

Alzheimer's disease is a neurodegenerative disorder associated with age, and is
characterized by pathological markers such as amyloid-beta plaques and neurofibrillary …

Melatonin and novel melatonin-based therapies such as melatonin-containing hybrid
molecules, melatonin analogues, and melatonin derivatives have been investigated as …

The structures of melatonin and ferulic acid were merged into tertiary amide-based histone
deacetylase 6 (HDAC6) inhibitors to develop multi-target-directed inhibitors for …

Background Alzheimer's disease (AD) is the most frequently occurring type of dementia.
Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably …

Melatonin (MLT) is a neurohormone that is regulated by the circadian clock and plays
multifunctional roles in numerous neurodegenerative disorders, such as Alzheimer's …

A series of multitarget-directed ligands (MTDLs) was designed by functionalizing a pseudo-
irreversible butyrylcholinesterase (BChE) inhibitor. The obtained hybrids were investigated …