Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Testosterone is essential for maintaining spermatogenesis and male fertility. However, the
molecular mechanisms by which testosterone acts have not begun to be revealed until …

Cell adhesion is crucial for the assembly of individual cells into the three-dimensional
tissues of animals. Cells do not simply “stick” together to form tissues, but rather are …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

In a recently developed human breast cancer model, treatment of tumor cells in a 3-
dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking …

The genome-wide program of gene expression during the cell division cycle in a human
cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of> 850 …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

▪ Abstract The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (ECs).
In the late embryonic and early postnatal period, these cells respond to inducing factors …

Spermatogenesis and male fertility are dependent upon the presence of testosterone in the
testis. In the absence of testosterone or the androgen receptor, spermatogenesis does not …

The long bones of the developing skeleton, such as those of the limb, arise from the process
of endochondral ossification, where cartilage serves as the initial anlage element and is …