Although the structure and composition of collagen have been studied by polarized light
microscopy since the early 19th century, many studies and reviews have paid little or no …

Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …

A tendon's ordered extracellular matrix (ECM) is essential for transmitting force but is also
highly prone to injury. How tendon cells embedded within and surrounding this dense ECM …

Scleraxis is a basic helix-loop-helix transcription factor that plays a central role in promoting
tenocyte proliferation and matrix synthesis during embryonic tendon development. However …

Tendon harbors a cell population that possesses stem cell characteristics such as
clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon …

Photoacoustic imaging (PAI) has emerged as a molecular-selective imaging technology
based on optical absorption contrast. Dichroism-sensitive photoacoustic (DS-PA) imaging …

Although the molecular mechanisms behind tendon disease remain obscure, aberrant
stromal matrix turnover and tissue hypervascularity are known hallmarks of advanced …

Tendons are collagenous soft tissues that transmit loads between muscles and bones.
Depending on their anatomical function, tendons are classified as positional or energy …

The forelimb superficial digital flexor tendon (SDFT) is an energy‐storing tendon that is
highly susceptible to injury during activities such as galloping and jumping, such that it is …

Actin is a central mediator between mechanical force and cellular phenotype. In tendons, it
is speculated that mechanical stress deprivation regulates gene expression by reducing …