TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface

M Alves, P Asbell, M Dogru, G Giannaccare, A Grau… - The Ocular Surface, 2023 - Elsevier
Environmental risk factors that have an impact on the ocular surface were reviewed and
associations with age and sex, race/ethnicity, geographical area, seasonality, prevalence …

[HTML][HTML] Oxidative stress in the eye and its role in the pathophysiology of ocular diseases

EW Böhm, F Buonfiglio, AM Voigt, P Bachmann, T Safi… - Redox Biology, 2023 - Elsevier
Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

The effects of exposure to solar radiation on human health

RE Neale, RM Lucas, SN Byrne, L Hollestein… - Photochemical & …, 2023 - Springer
This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal
Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of …

[HTML][HTML] Pharmacological treatment strategies of pterygium: drugs, biologics, and novel natural products

SS Baheran, RG Alany, S Schwikkard, W Muen… - Drug Discovery …, 2023 - Elsevier
Pterygium is a fibrovascular tissue growth invading the cornea. Adjunctive treatment post-
surgery includes conventional immunosuppressants as well as antiviral drugs. The use of …

UV protection in the cornea: failure and rescue

T Volatier, B Schumacher, C Cursiefen, M Notara - Biology, 2022 - mdpi.com
Simple Summary The sun is a deadly laser, and its damaging rays harm exposed tissues
such as our skin and eyes. The skin's protection and repair mechanisms are well understood …

Single-cell RNA sequencing reveals the complex cellular niche of pterygium

X Zhang, P Han, J Qiu, F Huang, Q Luo, J Cheng… - The Ocular Surface, 2024 - Elsevier
Purpose Pterygium is a vision-threatening conjunctival fibrovascular degenerated disease
with a high global prevalence up to 12%, while no absolute pharmacotherapy has been …

Transcriptome analysis of pterygium and pinguecula reveals evidence of genomic instability associated with chronic inflammation

MF Suarez, J Echenique, JM López, E Medina… - International Journal of …, 2021 - mdpi.com
Solar damage due to ultraviolet radiation (UVR) is implicated in the development of two
proliferative lesions of the ocular surface: pterygium and pinguecula. Pterygium and …

Ocular-Surface Regeneration Therapies for Eye Disorders: The State of the Art

M Posarelli, D Romano, D Tucci, G Giannaccare… - BioTech, 2023 - mdpi.com
The ocular surface is a complex structure that includes cornea, conjunctiva, limbus, and tear
film, and is critical for maintaining visual function. When the ocular-surface integrity is altered …

Uncovering the role of transient receptor potential channels in pterygium: a machine learning approach

Y Cai, T Zhou, J Chen, X Cai, Y Fu - Inflammation Research, 2023 - Springer
Objectives We aimed at identifying the role of transient receptor potential (TRP) channels in
pterygium. Methods Based on microarray data GSE83627 and GSE2513, differentially …

Contribution of matrix metalloproteinase-2 genotypes to Taiwan pterygium risk

PS Hu, NY Hsia, ZH Wang, HC Chen, TC Hsia, ML Lin… - in vivo, 2024 - iv.iiarjournals.org
Background/Aim: In the literature, the studies about the role of matrix metalloproteinase-2
(MMP-2) in pterygium diagnosis are mainly based on its protein expression. The role of …