Macrophages are the most abundant cells within the tumor stroma displaying noticeable
plasticity, which allows them to perform several functions within the tumor microenvironment …

As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer
efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for …

Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

Purpose: Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates
NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely …

Diffuse midline glioma (DMG) is an incurable malignancy with the highest mortality rate
among pediatric brain tumors. While radiotherapy and chemotherapy are the most common …

Many anticancer immunotherapeutic agents, including the monoclonal immune checkpoint
blocking antibodies, toll-like receptor (TLR) agonists, cytokines and immunostimulatory …

Cancer virotherapy is a paradigm-shifting treatment modality based on virus-mediated
oncolysis and subsequent antitumor immune responses. Clinical trials of currently available …

Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

Mesenchymal stem cells (MSCs) loaded with oncolytic viruses are presently being
investigated as a new modality of advanced/metastatic tumors treatment and enhancement …

Background Diffuse midline gliomas (DMG), including brainstem diffuse intrinsic pontine
glioma (DIPG), are incurable pediatric high-grade gliomas (pHGG). Mutations in the H3 …