This Perspective is a continuation of our analysis of US FDA-approved small-molecule drugs
(1938–2012) containing nitrogen heterocycles. In this study we report drug structure and …

Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …

In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …

Borrowing hydrogen is a process that is used to diversify the synthetic utility of commodity
alcohols. A catalyst first oxidizes an alcohol by removing hydrogen to form a reactive …

Herein, a facile and general electroreductive deuteration of unactivated alkyl halides (X= Cl,
Br, I) or pseudo-halides (X= OMs) using D2O as the economical deuterium source was …

Despite widespread use of the deuterium isotope effect, selective deuterium labeling of
chemical molecules remains a major challenge. Herein, a facile and general …

Deuterated chemicals are becoming irreplaceable in pharmaceutical engineering, material
science and synthetic chemistry. Many excellent reviews have discussed acid/base …

Emerging SARS-CoV-2 variants continue to cause waves of new infections globally.
Developing effective antivirals against SARS-CoV-2 and its variants is an urgent task. The …