Simple Summary The epithelial to mesenchymal transition (EMT) is a well-documented
process in the study of cancer metastases. The cytoskeleton is an intricate network involved …

Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Intrinsically disordered proteins (IDPs) are enriched in signaling and regulatory functions
because disordered segments permit interaction with several proteins and hence the re-use …

Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors
including environmental and genetic ones participate in BC development. Metastasis of BC …

The cyclin-dependent kinase (Cdk) inhibitor p27 (also known as KIP1) regulates cell
proliferation, cell motility and apoptosis. Interestingly, the protein can exert both positive and …

Recently, microRNAs (miRNAs) have been discovered to have a role in metastasis. Here we
describe how miRNAs are involved in advanced stages of tumour progression, stressing …

Abstract p27 binds and inhibits cyclin-CDK to arrest the cell cycle. p27 also regulates other
processes including cell migration and development independent of its cyclin-dependent …

Human pluripotent stem cells offer promise for use in cell-based therapies for brain injury
and diseases. However, their cellular behavior is poorly understood. Here we show that the …

While targeting experiments carried out on the genes encoding many cell cycle regulators
have challenged our views of cell cycle control, they also suggest that redundancy might not …