Without effective countermeasures, the musculoskeletal system is altered by the microgravity
environment of long-duration spaceflight, resulting in atrophy of bone and muscle tissue, as …

In vivo, tibial loading in mice is increasingly used to study bone adaptation and
mechanotransduction. To achieve standardized and defined experimental conditions …

Osteoporosis is a major health problem, making bones fragile and susceptible to fracture.
Previous works showed that mechanical loading stimulated bone formation and accelerated …

Bone loss caused by ionizing radiation is a potential health concern for radiotherapy
patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation …

Background and Purpose: As a feasible approach, radiotherapy has a great role in prostate
cancer (Pca) management. However, Pca patients have an increased risk of femoral head …

A manned mission to Mars and the establishment of the first human settlement in outer
space was once a mere figment of science fiction but is now being planned and expected to …

Radiation therapy is one of the routine treatment modalities for cancer patients. Ionizing
radiation (IR) can induce bone loss, and consequently increases the risk of fractures with …

Axial loading in rodents provides a controlled setting for mechanical loading, because load
and subsequent strain, frequency, number of cycles and rest insertion between cycles, are …

Bone continually adapts to changing external loading conditions via (re) modeling
(modeling and remodeling) processes. While physical activity is known to beneficially …

Although mechanical loading is essential for maintaining bone health and combating
osteoporosis, its practical application is limited to a large extent by the high variability in …