Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell
walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing …

Abstract Glycoside hydrolase family 18 (GH18) chitinases, which catalyze the
biodegradation of β-1, 4 glycosidic bond in amino polysaccharides via a substrate-assisted …

Sustainable agriculture requires insecticides that are selective between insects and
mammals and even between harmful and beneficial insects. Lepidoptera includes the …

Camptothecin (CPT) is a prominent molecule in natural product research because of its
application prospects in medicine and agriculture. In this study, CPT and its derivatives were …

Multitarget inhibitors of insect chitinolytic enzymes are promising sources of green
insecticides. Machine learning (ML) is an emerging virtual screening method that can …

Multitarget insecticides are more likely to achieve comprehensive regulation of insects with a
low risk of resistance. Insect chitinolytic enzymes, including GH18 chitinases and GH20 β-N …

Small-molecule inhibitors of insect chitinolytic enzymes are potential insecticides. However,
the reported inhibitors that target one enzyme usually exhibit unsatisfactory bioactivity. On …

Asian corn borer (Ostrinia furnacalis) is one of the most destructive pests in agriculture.
Three chitinases Of ChtI, Of ChtII, and Of Chi-h are regarded as potential targets for …

Chitinase (EC 3.2. 1.14) is an enzyme to breakdown β-1, 4-glycosidic bonds in chitin and
chitooligosaccharides. The loss of chitinase enzymatic activity in insects results in severe …

The duplication of chitinase 5 (Cht5) into two to five different genes has been reported only
in mosquito species to date. Here, we report the duplication of Cht5 genes (LmCht5-1 and …