Medicinal chemistry is still clearly dominated by organic chemistry. Most of the marketed
drugs are purely organic molecules. The right-hand neighbors of carbon in the periodic …

Importance Prospective data on the risk of hepatocellular carcinoma (HCC) according to
dose and duration of aspirin therapy are limited. Objective To examine the potential benefits …

PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal
anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of prostaglandin …

Background Patients with arthritis and vascular disease may receive both low-dose aspirin
and other nonsteroidal antiinflammatory drugs. We therefore investigated potential …

Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705−762 | Chemical Reviews ACS
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

Cyclooxgenases are key enzymes of lipid signaling. They carry out the first step in the
production of prostaglandins, important mediators of inflammation, pain, cardiovascular …

Prostaglandins were discovered in human semen in 1930, but their low concentrations and
instability precluded identification for nearly 30 years (for a brief historical review, see Ref …

The first crystal structure of human cyclooxygenase-2, in the presence of a selective
inhibitor, is similar to that of cyclooxygenase-1. The structure of the NSAID binding site is …

The rate-limiting enzyme in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

Naproxen ((S)-6-methoxy-α-methyl-2-naphthaleneacetic acid) is a powerful non-selective
non-steroidal anti-inflammatory drug that is extensively used as a prescription and over-the …