Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to
preserve appropriate self-renewal and differentiation capacities. However, their prolonged in …

During human preimplantation development the totipotent zygote divides and undergoes a
number of changes that lead to the first lineage differentiation in the blastocyst displaying …

Recruitment of transcription factors (TFs) to repressed genes in euchromatin is essential to
activate new transcriptional programs during cell differentiation. However, recruitment of all …

Histone methylation plays an important role in gene transcription and chromatin
organization and is linked to the silencing of a number of critical tumor suppressor genes in …

Background Human induced pluripotent stem cells (hiPSCs) play roles in both disease
modelling and regenerative medicine. It is critical that the genomic integrity of the cells …

It has previously been shown that selenite can act as an antitumor agent and inhibit cancer
cell growth, although the mechanism responsible for this effect is not well understood. In this …

As a newly-invented and highly-efficiency strobilurin fungicide, pyraoxystrobin (SYP-3343)
has been recognized as a highly poisonous toxin for a variety of aquatic organisms …

Pluripotent stem cells (PSCs) hold great potential both in studies on developmental biology
and clinical practice. Mitochondrial metabolism that encompasses pathways that generate …

A systematic study on the biological effects of simulated microgravity (sµg) on human
pluripotent stem cells (hPSC) is still lacking. Here, we used a fast-rotating 2-D clinostat to …

The study of proliferation regulation in human pluripotent stem cells is crucial to gain insights
into understanding the physiology of these cells. However, redox regulation of the …