Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …

SUMMARY A syndemic is defined as the convergence of two or more diseases that act
synergistically to magnify the burden of disease. The intersection and syndemic interaction …

The resurgence of tuberculosis worldwide has intensified research efforts directed at
examining the host defense and pathogenic mechanisms operative in Mycobacterium …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

Mycobacteria are endowed with mechanisms through which they can evade the onslaught
of host defense response. These mechanisms are discussed including diminishing the …

Myelopoiesis ensures the steady state of the myeloid cell compartment. Technological
advances in fate mapping and genetic engineering, as well as the advent of single cell RNA …

During tuberculosis (TB) infection, the granuloma provides the microenvironment in which
antigen‐specific T cells colocate with and activate infected macrophages to inhibit the …

Macrophage activation determines the outcome of infection by Mycobacterium tuberculosis
(Mtb). Interferon-γ (IFN-γ) activates macrophages by driving Janus tyrosine kinase …