Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

In Parkinson's disease, intracellular α-synuclein inclusions form in neurons. We suggest that
prion-like behavior of α-synuclein is a key component in Parkinson's disease pathogenesis …

The abnormal aggregation of a small number of known proteins underlies the most common
human neurodegenerative diseases. In tauopathies and synucleinopathies, the normally …

Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-
like domain-containing protein and component of pathological intracellular aggregates …

The diagnosis of PD might be in difficulty, especially in the early stages. Therefore, the
identification of novel biomarkers is imperative for the diagnosis and monitoring disease …

The presence of Lewy bodies, mainly consisting of aggregated α-synuclein, is a pathological
hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The α …

The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy
pathology, is a phenomenon central to Parkinson's disease (PD) pathogenesis. The …

Parkinson's disease (PD) is an adult onset neurodegenerative disease that is characterized
by selective degeneration of neurons primarily in the substantia nigra. At present, the …

Parkinson's disease (PD) is a neurodegenerative, progressive disease without a cure. To
prevent PD onset or at least limit neurodegeneration, a better understanding of the …

Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains,
nearly all α-syn accumulated within Lewy bodies in Parkinson disease brains is …