Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model

JE La Marca, HE Richardson - Frontiers in cell and developmental …, 2020 - frontiersin.org
The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many
functions, regulating a diversity of processes: from cell movement during embryogenesis to …

Drosophila as a Model Organism to Study Basic Mechanisms of Longevity

AA Ogienko, ES Omelina, OV Bylino, MA Batin… - International Journal of …, 2022 - mdpi.com
The spatio-temporal regulation of gene expression determines the fate and function of
various cells and tissues and, as a consequence, the correct development and functioning of …

A conserved STRIPAK complex is required for autophagy in muscle tissue

Y Guo, Q Zeng, D Brooks… - Molecular Biology of the …, 2023 - Am Soc Cell Biol
Autophagy is important for cellular homeostasis and to prevent the abnormal accumulation
of proteins. While many proteins that comprise the canonical autophagy pathway have been …

The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis

SC Herrera, EA Bach - International Journal of Molecular Sciences, 2021 - mdpi.com
The Jun N-terminal kinase (JNK) pathway is an evolutionary conserved kinase cascade best
known for its roles during stress-induced apoptosis and tumor progression. Recent findings …

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

A Kaya-Copur, F Marchiano, MY Hein, D Alpern… - elife, 2021 - elifesciences.org
Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-
producing myofibrils. During development, the size of individual muscle fibers must …

Identification and functional analysis of CG3526 in spermatogenesis of Drosophila melanogaster

Q Hu, Y Xiao, R Wei, T Tang, L Wen, Y Lu… - Insect …, 2024 - Wiley Online Library
Spermatogenesis is a critical part of reproduction in insects; however, its molecular
mechanism is still largely unknown. In this study, we identified a testis‐specific gene …

Cellular impacts of striatins and the STRIPAK complex and their roles in the development and metastasis in clinical cancers

AX Li, TA Martin, J Lane, WG Jiang - Cancers, 2023 - mdpi.com
Simple Summary The STRIPAK (striatin-interacting phosphatase and kinase) complex and
its central components, striatins (STRNs), have attracted significant interest with regard to …

Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

M Ahmed, Y Kojima, I Masai - Elife, 2022 - elifesciences.org
In the vertebrate retina, an interplay between retinal ganglion cells (RGCs), amacrine (AC),
and bipolar (BP) cells establishes a synaptic layer called the inner plexiform layer (IPL). This …

Mob4 is essential for spermatogenesis in Drosophila melanogaster

IB Santos, A Wainman, J Garrido-Maraver, V Pires… - Genetics, 2023 - academic.oup.com
Gamete formation is essential for sexual reproduction in metazoans. Meiosis in males gives
rise to spermatids that must differentiate and individualize into mature sperm. In Drosophila …

PTP61F mediates cell competition and mitigates tumorigenesis

JE La Marca, LF Willoughby, K Allan, M Portela… - International Journal of …, 2021 - mdpi.com
Tissue homeostasis via the elimination of aberrant cells is fundamental for organism
survival. Cell competition is a key homeostatic mechanism, contributing to the recognition …