Bacterial vaginosis: current diagnostic avenues and future opportunities

MJ Redelinghuys, J Geldenhuys, H Jung… - Frontiers in cellular and …, 2020 - frontiersin.org
A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen
peroxide producing bacteria, which provide protection against infections by maintaining a …

Mechanisms of synergy in polymicrobial infections

JL Murray, JL Connell, A Stacy, KH Turner… - Journal of …, 2014 - Springer
Communities of microbes can live almost anywhere and contain many different species.
Interactions between members of these communities often determine the state of the habitat …

The influence of sexual activity on the vaginal microbiota and Gardnerella vaginalis clade diversity in young women

LA Vodstrcil, J Twin, SM Garland, CK Fairley… - PloS one, 2017 - journals.plos.org
Objectives To examine the influence of sexual activity on the composition and consistency of
the vaginal microbiota over time, and distribution of Gardnerella vaginalis clades in young …

'Multi-omics' data integration: applications in probiotics studies

ID Kwoji, OA Aiyegoro, M Okpeku, MA Adeleke - npj Science of Food, 2023 - nature.com
The concept of probiotics is witnessing increasing attention due to its benefits in influencing
the host microbiome and the modulation of host immunity through the strengthening of the …

Combined oral and topical antimicrobial therapy for male partners of women with bacterial vaginosis: acceptability, tolerability and impact on the genital microbiota of …

EL Plummer, LA Vodstrcil, JA Danielewski, GL Murray… - PloS one, 2018 - journals.plos.org
Objectives Recurrence following recommended treatment for bacterial vaginosis is
unacceptably high. While the pathogenesis of recurrence is not well understood, recent …

The genital tract and rectal microbiomes: their role in HIV susceptibility and prevention in women

SS Abdool Karim, C Baxter… - Journal of the …, 2019 - Wiley Online Library
Introduction Young women in sub‐Saharan Africa are disproportionately affected by HIV,
accounting for 25% of all new infections in 2017. Several behavioural and biological factors …

Influence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections

A Aiyar, AJ Quayle, LR Buckner… - Frontiers in cellular …, 2014 - frontiersin.org
The natural history of genital Chlamydia trachomatis infections can vary widely; infections
can spontaneously resolve but can also last from months to years, potentially progressing to …

First trimester levels of BV-associated bacteria and risk of miscarriage among women early in pregnancy

DB Nelson, AL Hanlon, G Wu, C Liu… - Maternal and child health …, 2015 - Springer
Objectives Prior studies have examined the role of bacterial vaginosis (BV) and increased
risk of miscarriage; however the risk has been modest and many BV positive pregnant …

Screening of Compounds against Gardnerella vaginalis Biofilms

C Gottschick, SP Szafranski, B Kunze, H Sztajer… - PloS one, 2016 - journals.plos.org
Bacterial vaginosis (BV) is a common infection in reproductive age woman and is
characterized by dysbiosis of the healthy vaginal flora which is dominated by Lactobacilli …

Normal flora and bacterial vaginosis in pregnancy: an overview

MJ Redelinghuys, MM Ehlers, AW Dreyer… - Critical reviews in …, 2016 - Taylor & Francis
The female genital tract is an intricate, yet balanced ecosystem that hosts a variety of
different residential microflora. The physiological changes that occur during pregnancy may …