Real-time fluorescence imaging in intraoperative decision making for cancer surgery

LJ Lauwerends, PBAA van Driel, RJB de Jong… - The Lancet …, 2021 - thelancet.com
Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …

Unique properties of surface-functionalized nanoparticles for bio-application: functionalization mechanisms and importance in application

F Ahmad, MM Salem-Bekhit, F Khan, S Alshehri… - Nanomaterials, 2022 - mdpi.com
This review tries to summarize the purpose of steadily developing surface-functionalized
nanoparticles for various bio-applications and represents a fascinating and rapidly growing …

First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

Z Hu, C Fang, B Li, Z Zhang, C Cao, M Cai… - Nature biomedical …, 2020 - nature.com
The second near-infrared wavelength window (NIR-II, 1,000–1,700 nm) enables
fluorescence imaging of tissue with enhanced contrast at depths of millimetres and at …

Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine

S Pan, A Ding, Y Li, Y Sun, Y Zhan, Z Ye… - Chemical Society …, 2023 - pubs.rsc.org
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Fluorescence-guided surgery

T Nagaya, YA Nakamura, PL Choyke… - Frontiers in …, 2017 - frontiersin.org
Surgical resection of cancer remains an important treatment modality. Despite advances in
preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate …

Surgical navigation for malignancies guided by near‐infrared‐II fluorescence imaging

RQ Yang, KL Lou, PY Wang, YY Gao, YQ Zhang… - Small …, 2021 - Wiley Online Library
Near‐infrared (NIR) fluorescence imaging is an emerging noninvasive imaging modality,
with unique advantages in guiding tumor resection surgery, thanks to its high sensitivity and …

Advanced nanotechnology leading the way to multimodal imaging‐guided precision surgical therapy

C Wang, W Fan, Z Zhang, Y Wen, L Xiong… - Advanced …, 2019 - Wiley Online Library
Surgical resection is the primary and most effective treatment for most patients with solid
tumors. However, patients suffer from postoperative recurrence and metastasis. In the past …

Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation …

LSF Boogerd, CES Hoogstins, DP Schaap… - The Lancet …, 2018 - thelancet.com
Background Tumour-targeted fluorescence imaging has the potential to advance current
practice of oncological surgery by selectively highlighting malignant tissue during surgery …

Image-guided surgery in patients with pancreatic cancer: first results of a clinical trial using SGM-101, a novel carcinoembryonic antigen-targeting, near-infrared …

CES Hoogstins, LSF Boogerd… - Annals of surgical …, 2018 - Springer
Background Near-infrared (NIR) fluorescence is a promising novel imaging technique that
can aid in intraoperative demarcation of pancreatic cancer (PDAC) and thus increase radical …

Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

M Koller, SQ Qiu, MD Linssen, L Jansen… - Nature …, 2018 - nature.com
During the last decade, the emerging field of molecular fluorescence imaging has led to the
development of tumor-specific fluorescent tracers and an increase in early-phase clinical …