Oxidation of drugs during drug product development: problems and solutions

A Gabrič, Ž Hodnik, S Pajk - Pharmaceutics, 2022 - mdpi.com
Oxidation is the second most common degradation pathway for pharmaceuticals, after
hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex …

Functional modification of HHCB: Strategy for obtaining environmentally friendly derivatives

X Li, W Gu, B Chen, Z Zhu, B Zhang - Journal of Hazardous Materials, 2021 - Elsevier
Galaxolide (HHCB), one of the most widely used synthetic musks in personal care products
(PCPs), has been recognized as an emerging contaminant with potential human health …

Chemometrics approaches in forced degradation studies of pharmaceutical drugs

B Roberto de Alvarenga Junior, R Lajarim Carneiro - Molecules, 2019 - mdpi.com
Chemometrics is the chemistry field responsible for planning and extracting the maximum of
information of experiments from chemical data using mathematical tools (linear algebra …

Modeling and regulation of neonicotinoid insecticides exposure in agricultural planting areas for reducing the human health risks

Y Zhao, X Li, Q Li, H Yang, W Zhao, Y Li - Journal of Cleaner Production, 2021 - Elsevier
The rapid socio-economic development and improved living standards have increased
people's awareness about environmental protection and the health of agricultural products …

Disposable cerium oxide/graphene nanosheets based sensor for monitoring acebutolol in environmental samples and bio-fluids

SV Selvi, N Nataraj, TW Chen, SM Chen, P Balu… - Journal of …, 2022 - Elsevier
The production and utilization of medicines strives to be an essential factor in the modern
world in treatment, diagnosis and prevention. On the other hand, the medical discharge and …

Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity

P Jithavech, P Suwattananuruk, Hasriadi… - PLoS …, 2022 - journals.plos.org
Curcumin is a polyphenol compound that alleviates several neuroinflammation-related
diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy …

A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking

B Le Daré, S Allard, R Bouvet, A Baert… - International journal of …, 2020 - Springer
Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-
stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in …

Identification of the chemical components and metabolites of tripterygium glycoside tablets in mice by HPLC-Q/TOF MS

D Zhang, L Qu, Z Wang, J Zhang - Journal of Chromatography B, 2019 - Elsevier
Tripterygium glycosides tablets (TGT) contain the main extract of tripterygium and are widely
used clinically to treat autoimmune diseases such as rheumatoid arthritis and nephrotic …

Further exploration of the collision‐induced dissociation of select beta blockers: Acebutolol, atenolol, bisoprolol, carteolol, and labetalol

MJ Carlo, AL Patrick - Journal of Mass Spectrometry, 2023 - Wiley Online Library
Beta blockers are a class of drugs commonly used to treat heart‐related diseases; they are
also regulated under the World Anti‐Doping Agency. Tandem mass spectrometry is often …

LC and LC–MS/MS Studies for the Separation and Identification of Impurities and Degradation Products of Betaxolol

A Chmangui, M Safta, MR Driss, S Touil… - Journal of …, 2024 - academic.oup.com
Betaxolol (Bx) is a selective β1 receptor blocker used in the treatment of hypertension and
glaucoma. The aim of the present work was to demonstrate an approach involving use of …