DNA is stored in a highly compact, condensed phase in viruses, bacteria and eukaryotes.
Co (NH 3) 6 3+ is a well-known inorganic cation that can induce DNA condensation, and …

Polycations that are degradable by reduction of disulfide bonds are developed for
applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of …

A novel family of precision-engineered gene vectors with well-defined structures built on
trehalose and trehalose-based macrocycles (cyclotrehalans) comprising linear or cyclic …

In the present study, a series of copolymers (PAMD-Ch) was synthesized by grafting
polymeric Plerixafor/AMD3100 (PAMD) with different amounts of cholesterol and the effect of …

Acute kidney injury (AKI) is a global healthcare burden characterized by rapid loss of renal
function and high morbidity and mortality. Chemokine receptor CXCR4 participates in the …

The effective clinical translation of messenger RNA (mRNA), small interfering RNA (siRNA),
and microRNA (miRNA) for therapeutic purposes hinges on the development of efficient …

Purpose To determine the effect of PEG modification on pharmacologic and gene delivery
properties of polymeric CXCR4 antagonist based on Plerixafor. Methods Po lymeric …

The study was aimed to investigate the effect of chemical modification of branched poly
ethyleneimine (PEI) on chelation of transition metal ions (Me 2+) including Zn 2+, Cu 2+ or …

Antibody-drug conjugates (ADCs) offer new therapeutic options for advanced cancer
patients through precision killing with fewer side effects. The stability and efficacy of ADCs …

The metal complex-based carriers are emerging likely as a new type of gene-delivery
systems prone to systematic structural alteration and chemical tailoring. In our work, the DNA …