Design principles of regulatory networks underlying epithelial mesenchymal plasticity in cancer cells
Phenotypic plasticity is a hallmark of cancer and drives metastatic disease and drug
resistance. The dynamics of epithelial mesenchymal plasticity is driven by complex …
resistance. The dynamics of epithelial mesenchymal plasticity is driven by complex …
Mutually exclusive teams-like patterns of gene regulation characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma
Neuroblastoma is the most frequent extracranial pediatric tumor and leads to 15% of all
cancer-related deaths in children. Tumor relapse and therapy resistance in neuroblastoma …
cancer-related deaths in children. Tumor relapse and therapy resistance in neuroblastoma …
Data‐and theory‐driven approaches for understanding paths of epithelial–mesenchymal transition
Reversible transitions between epithelial and mesenchymal cell states are a crucial form of
epithelial plasticity for development and disease progression. Recent experimental data and …
epithelial plasticity for development and disease progression. Recent experimental data and …
State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia
DE Frankhouser, RC Rockne, L Uechi, D Zhao… - Leukemia, 2024 - nature.com
Chronic myeloid leukemia (CML) is initiated and maintained by BCR:: ABL which is clinically
targeted using tyrosine kinase inhibitors (TKIs). TKIs can induce long-term remission but are …
targeted using tyrosine kinase inhibitors (TKIs). TKIs can induce long-term remission but are …
[HTML][HTML] Proneural-mesenchymal antagonism dominates the patterns of phenotypic heterogeneity in glioblastoma
BV Harshavardhan, MK Jolly - Iscience, 2024 - cell.com
The aggressive nature of glioblastoma (GBM)–one of the deadliest forms of brain tumors–is
majorly attributed to underlying phenotypic heterogeneity. Early attempts to classify this …
majorly attributed to underlying phenotypic heterogeneity. Early attempts to classify this …
[HTML][HTML] Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided …
P Bhattacharya, A Linnenbach, AP South… - …, 2024 - pmc.ncbi.nlm.nih.gov
Immune checkpoint inhibition (ICI) has emerged as a critical treatment strategy for
squamous cell carcinoma of the head and neck (HNSCC) that halts the immune escape of …
squamous cell carcinoma of the head and neck (HNSCC) that halts the immune escape of …