Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Ambient air pollution increases the risk of cerebrovascular and neuropsychiatric disorders through induction of inflammation and oxidative stress

O Hahad, J Lelieveld, F Birklein, K Lieb… - International journal of …, 2020 - mdpi.com
Exposure to ambient air pollution is a well-established determinant of health and disease.
The Lancet Commission on pollution and health concludes that air pollution is the leading …

Utilizing electrostatic effect in fibrous filters for efficient airborne particles removal: Principles, fabrication, and material properties

Y Gao, E Tian, Y Zhang, J Mo - Applied Materials Today, 2022 - Elsevier
Particulate matter (PM) poses a severe health threat to the public, and fibrous filtration is a
powerful method for efficient PM removal. Arming the fibers with electrostatic effect is a gold …

Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease

M Tsalenchuk, SM Gentleman, SJ Marzi - npj Parkinson's Disease, 2023 - nature.com
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

Air pollution, depressive and anxiety disorders, and brain effects: a systematic review

CG Zundel, P Ryan, C Brokamp, A Heeter, Y Huang… - Neurotoxicology, 2022 - Elsevier
Accumulating data suggest that air pollution increases the risk of internalizing
psychopathology, including anxiety and depressive disorders. Moreover, the link between …

Effects of air pollution particles (ultrafine and fine particulate matter) on mitochondrial function and oxidative stress–Implications for cardiovascular and …

A Daiber, M Kuntic, O Hahad, LG Delogu… - Archives of biochemistry …, 2020 - Elsevier
Environmental pollution is a major cause of global mortality and burden of disease. All
chemical pollution forms together may be responsible for up to 12 million annual excess …

To promote healthy aging, focus on the environment

DW Belsky, AA Baccarelli - Nature aging, 2023 - nature.com
To build health equity for an aging world marked by dramatic disparities in healthy lifespan
between countries, regions and population groups, research at the intersections of biology …

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

T Pandics, D Major, V Fazekas-Pongor, Z Szarvas… - Geroscience, 2023 - Springer
The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia …

L Calderón-Garcidueñas, A González-Maciel… - Environmental …, 2020 - Elsevier
Fine particulate air pollution (PM 2.5) exposures are linked with Alzheimer's and Parkinson's
diseases (AD, PD). AD and PD neuropathological hallmarks are documented in children …

Airborne particulate matter induces oxidative damage, DNA adduct formation and alterations in DNA repair pathways

EM Quezada-Maldonado, Y Sánchez-Pérez… - Environmental …, 2021 - Elsevier
Air pollution, which includes particulate matter (PM), is classified in group 1 as a carcinogen
to humans by the International Agency for Research in Cancer. Specifically, PM exposure …