Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …

The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Understanding how gene expression programs are controlled requires identifying regulatory
relationships between transcription factors and target genes. Gene regulatory networks are …

Yeast cells sense the amount and quality of external nutrients through multiple
interconnected signaling networks, which allow them to adjust their metabolism …

The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm.
The inner nuclear membrane (INM) functions in essential nuclear processes including …

We compared the transcriptomes of Saccharomyces cerevisiae cells growing under steady-
state conditions on 21 unique sources of nitrogen. We found 506 genes differentially …

In the presence of glucose, yeast undergoes an important remodelling of its metabolism.
There are changes in the concentration of intracellular metabolites and in the stability of …

Nitrogen is one of the most important essential nutrient sources for biogenic activities.
Regulation of nitrogen metabolism in microorganisms is complicated and elaborate. For this …

Polypeptides exiting the ribosome must fold and assemble in the crowded environment of
the cell. Chaperones and other protein homeostasis factors interact with newly translated …